The principles in our lab are shaped around the premise that biological responses of astrocytes and microglia to neurodegenerative diseases aren’t neatly categorized into binary relationships. Rather, the responses of these critical cell populations are shaped by a continuum of factors driving aging and/or disease-related heterogeneity. Importantly, deciphering the heterogeneity and susceptibility of these cell populations may provide exciting clues as to the mechanisms underlying brain dysfunction. Approaches in the lab are geared around applying multidisciplinary approaches to study the complex heterogeneous inflammatory response of astrocytes and microglia across a variety of neurodegenerative disease models. Cutting-edge technologies using single-cell RNA sequencing (scRNAseq), spatial transcriptomics, fluorescently activated cell sorting (FACS), cell-specific conditional knockout (cKO) models, and bioinformatics are just some of the resources at our disposal to answer our questions.